MAP Program

Discover, Reveal and Target

Proprietary Technology Platform

Our proprietary technology platform, which we refer to as our Mutation-Allostery-Pharmacology, or MAP, platform, is built on three central pillars:

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Discover

Through comprehensive analysis of population-level genetic sequencing data, we identify oncogenic mutations among hundreds of unique alterations within a single gene. Our MAP platform algorithm uses genetic and proteomic features to rank mutations for potential oncogenicity. We use our algorithm as a machine learning tool to classify mutations as either pathogenic or benign and predict the probability, or MAP score, that a mutation is pathogenic.
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Reveal

We confirm the oncogenicity of the identified mutations through cell and tumor models and reveal how these mutations drive conformational changes in proteins. This allows us to group subsets of mutations into families based upon similar protein structures and shared selectivity profiles.
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Target

Using these shared characteristics, we seek to develop single small molecule product candidates, each designed to inhibit only the intended mutation family.

Efficient Screening & Validation of Oncogenic Mutations

MAP Platform:

Black Diamond’s Tumor Agnostic Precision Medicine Strategy

Expanding the Opportunity for Precision Medicine in Oncology:

Expanding the Opportunity for Precision Medicine in Oncology